N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE - Names and Identifiers
N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE - Physico-chemical Properties
Molecular Formula | C25H26N2O5
|
Molar Mass | 434.48 |
Density | 1.235±0.06 g/cm3(Predicted) |
Boling Point | 572.6±50.0 °C(Predicted) |
Solubility | DMSO: soluble15mg/mL, clear |
Appearance | powder |
Color | white to beige |
pKa | 12.41±0.70(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
In vitro study | JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC 50 value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. |
In vivo study | JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice. |
N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE - Risk and Safety
N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE - Reference
Reference Show more | 1. [IF=5.914] Jing Xie et al."Short-chain fatty acids produced by Ruminococcaceae mediates α-Linolenic acid promote intestinal stem cells proliferation."Molecular Nutrition & Food Research. 2021 Oct 28 |
N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE - Preparation solution concentration reference
| 1mg | 5mg | 10mg |
---|
1 mM | 2.302 ml | 11.508 ml | 23.016 ml |
5 mM | 0.46 ml | 2.302 ml | 4.603 ml |
10 mM | 0.23 ml | 1.151 ml | 2.302 ml |
5 mM | 0.046 ml | 0.23 ml | 0.46 ml |
Last Update:2024-01-02 23:10:35
N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE - Reference Information
biological activity | JW55 is an effective and selective classical Wnt signaling pathway inhibitor, which works by inhibiting the PARP region of TNKS1/2. |
target | TargetValue Wnt () |
Target | Value |
in vitro study | JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC 50 value of 470 nM. JW55 is effective in the range of 1 to 5 μ m in SW480 cells and 0.01 to 5 μ m in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. |
in vivo study | JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice. |
Last Update:2024-04-09 21:54:55